Vasp ELISA Kit for Mouse(Mus musculus) | EIAab.comVasp ELISA Kit for Mouse(Mus musculus)

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Vasp (Gene name),

Vasodilator-stimulated phosphoprotein (Protein name ), VASP_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Vasp;

Protein name:

Vasodilator-stimulated phosphoprotein(VASP);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homotetramer (By similarity). Interacts with PFN1, PFN2, LPP, ACTN1 and ACTG1. Interacts, via the EVH1 domain, with the Pro-rich regions of ZYX. This interaction is important for targeting to focal adhesions and the formation of actin-rich structures at the apical surface of cells. Interacts, via the EVH1 domain, with the Pro-rich domain of Listeria monocytogenes actA. Interacts with APBB1IP. Interacts, via the Pro-rich domain, with the C-terminal SH3 domain of DNMBP.

Function:

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation.

Subcellular Location:

Cytoplasm Cytoplasm cytoskeleton Cell junction focal adhesion Cell projection lamellipodium membrane Cell projection filopodium membrane Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions.

Protein Attributes:

Sequence length:

375

Sequence:

50:

100:

150:

200:

250:

300:

350:

375:

RKELQKMKEE | IIEVFVQELR | KRGSP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08776

String:

P70460

Pfam:

PF11643

SMR:

P70460

UniGene:

Mm.9684

KEGG:

mmu:22323

Uniprot:

P70460

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ELISA Kit for Mouse VASP

Cat.:

E9578h

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96T

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ELISA Kit for Mouse VASP

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ELISA Kit for Mouse VASP

Cat.:

E9578b

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96T

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ELISA Kit for Mouse VASP

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E9578m

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96T

CLIA Kit for Mouse VASP

MSDS:

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CLIA Kit for Mouse VASP

Cat.:

U9578h

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Manual:

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96T

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CLIA Kit for Mouse VASP

Cat.:

U9578b

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MSDS:

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Packing:

96T

CLIA Kit for Mouse VASP

Cat.:

U9578m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse VASP

Cat.:

P9578Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse VASP

Cat.:

P9578Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse VASP

Monoclonal Antibody for Mouse VASP

Protein for Mouse VASP

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization."
Zimmer M. , Fink T. , Fischer L. , Hauser W. , Scherer K. , Lichter P. , Walter U.
Genomics36:227-233(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT THR-209
strain: 129.
2.

"Cyclic AMP- and cyclic GMP-dependent protein kinases differ in their regulation of cyclic AMP response element-dependent gene transcription."
Collins S.P. , Uhler M.D.
J. Biol. Chem.274:8391-8404(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PHOSPHORYLATION
strain: C57BL/6J.
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT THR-209
strain: C57BL/6J.
strain: NOD.
tissue: Adipose tissue.
tissue: Bone marrow.
tissue: Dendritic cell.
tissue: Spleen.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Kidney.
tissue: Mammary tumor.
5.

"Mena is required for neurulation and commissure formation."
Lanier L.M. , Gates M.A. , Witke W. , Menzies A.S. , Wehman A.M. , Macklis J.D. , Kwiatkowski D. , Soriano P. , Gertler F.B.
Neuron22:313-325(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
6.

"Directed actin polymerization is the driving force for epithelial cell-cell adhesion."
Vasioukhin V. , Bauer C. , Yin M. , Fuchs E.
Cell100:209-219(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
7.

"Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin."
Harbeck B. , Huttelmaier S. , Schlueter K. , Jockusch B.M. , Illenberger S.
J. Biol. Chem.275:30817-30825(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ACTN1; PFN1; PFN2; VCL AND ZYX;PHOSPHORYLATION AT SER-153 AND SER-235;MUTAGENESIS OF SER-153; SER-235 AND THR-274
8.

"The vasodilator-stimulated phosphoprotein promotes actin polymerisation through direct binding to monomeric actin."
Walders-Harbeck B. , Khaitlina S.Y. , Hinssen H. , Jockusch B.M. , Illenberger S.
FEBS Lett.529:275-280(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ACTG1;PHOSPHORYLATION;MUTAGENESIS OF 232-ARG-LYS-233
9.

"Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton."
Salazar M.A. , Kwiatkowski A.V. , Pellegrini L. , Cestra G. , Butler M.H. , Rossman K.L. , Serna D.M. , Sondek J. , Gertler F.B. , De Camilli P.
J. Biol. Chem.278:49031-49043(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNMBP
10.

"PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins."
Jenzora A. , Behrendt B. , Small J.V. , Wehland J. , Stradal T.E.
FEBS Lett.579:455-463(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APBB1IP
11.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
12.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Phosphorylation of VASP by AMPK alters actin binding and occurs at a novel site."
Thomson D.M. , Ascione M.P. , Grange J. , Nelson C. , Hansen M.D.
Biochem. Biophys. Res. Commun.414:215-219(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-318

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